Teratogenic action of platinum thymine blue

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Teratogenic action of platinum thymine blue.

The teratogenic activity of the antitumor agent cisplatinum-2-thymine (platinum thymine blue) was investigated in rats. Pregnant Wistar-derived albino rats were given single ip injections of an aqueous solution of platinum thymine blue (PTB) at one day of pregnancy from day 5 through day 14 (sperm day=day 0). The dosages used ranged from 20 to 80 mg/kg maternal body weight. At autopsy (day 20) ...

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Anticancer Active Compound, cis-Dichlorodiammineplatinum (II), ESR, Platinum Uracil Blue, Redox Properties ESR spectra of platinum uracil “blue” are discussed. Two main types of paramagnetic species have been found, one of which can be explained by assuming an unpaired electron spin delocal­ ized over dz2-orbitals of two equivalent Pt centers, the other one is attributed to a more localized d7 ...

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ژورنال

عنوان ژورنال: Life Sciences

سال: 1982

ISSN: 0024-3205

DOI: 10.1016/0024-3205(82)90701-9