Teratogenic action of platinum thymine blue

Teratogenic action of platinum thymine blue.

The teratogenic activity of the antitumor agent cisplatinum-2-thymine (platinum thymine blue) was investigated in rats. Pregnant Wistar-derived albino rats were given single ip injections of an aqueous solution of platinum thymine blue (PTB) at one day of pregnancy from day 5 through day 14 (sperm day=day 0). The dosages used ranged from 20 to 80 mg/kg maternal body weight. At autopsy (day 20) ...

Teratogenic action of the thyroid stimulating hormone and its interaction with trypan blue.

Teratogenic action of adenine on mouse embryos.

Several purine analogues are reported to show a teratogenic action in mammalian embryos when ad ministered at calculated dosage [reviewed by Giroud and Tuchmann-Duplessis-(1), Cahen (2) and Nishimura (3, 4); Kury et al. (5)]. We established that some methylated xanthines such as theophylline, theobromine and caffeine induce skeletal defects and subcutaneous hematoma in mice (6). Hypoxanthine al...

Teratogenic effects of trypan blue on hamster embryos.

L I T T L E information is available in the literature on the susceptibility of the hamster embryo to teratogens. Desoxycorticosterone acetate apparently has some teratogenic activity (Tedford & Risely, 1950), but the degree and type of abnormality produced by this agent in the hamster have not been recorded. Orsini (1952) has described naturally-occurring urogenital anomalies which appear in f...

ESR Studies on Platinum Uracil Blue

Anticancer Active Compound, cis-Dichlorodiammineplatinum (II), ESR, Platinum Uracil Blue, Redox Properties ESR spectra of platinum uracil “blue” are discussed. Two main types of paramagnetic species have been found, one of which can be explained by assuming an unpaired electron spin delocal­ ized over dz2-orbitals of two equivalent Pt centers, the other one is attributed to a more localized d7 ...